(Isithintelo segazi-ingqondo, BBB)
Umqobo wegazi-ubuchopho yenye yeendlela ezibalulekileyo zokuzikhusela ebantwini.Iqulunqwe ngeeseli zengqondo ze-capillary endothelial, iiseli ze-glial, kunye ne-choroid plexus, evumela kuphela iintlobo ezithile zeemolekyuli ezivela egazini ukuba zingene kwi-neurons yobuchopho kunye nezinye iiseli ezijikelezileyo, kwaye inokuthintela izinto ezahlukeneyo ezinobungozi ekungeneni kwizicubu zobuchopho.Ingqondo, njengenxalenye eyimfihlo nebalulekileyo yomzimba womntu, ilawula imisebenzi emininzi ebalulekileyo.Umqobo wegazi-ubuchopho unokuthintela izinto ezinobungozi egazini kwaye ukhusele ukhuseleko lwezicubu zengqondo.
Isifo sika-Alzheimer, AD
Isifo i-Alzheimer's (AD) sisifo se-neurodeergenerative esiqhubela phambili nesiqala ngokufihlakeleyo.Kwinkqubo yeklinikhi, i-dementia ebanzi ibonakala ngokukhubazeka kwememori, i-aphasia, i-aphasia, ukulahlekelwa kokuqaphela, ukuphazamiseka kwezakhono ezibonakalayo kunye neendawo, ukungasebenzi kakuhle, kunye nobuntu kunye nokutshintsha kokuziphatha.I-etiology ayikaziwa.I-dementia yangaphambi kwexesha ibhekisa kubantu abathi baba neempawu phambi kokuba babe neminyaka engama-65;Abantu abathi baba nokuphazamiseka kwengqondo emva kweminyaka engama-65 ubudala babizwa ngokuba yi-senile dementia.Ukwenzeka kwesifo i-Alzheimer's (AD) kudla ngokudityaniswa ne-β-Amyloid protein (A β) Ukuqokelela kunye ne-Tau protein entanglement zidityanisiwe, kwaye uphando olongezelelweyo ngokuthe ngcembe ludwelisa i-neuroinflammation njengenye yezinto ezibangela ukwenzeka kwe-AD.
Ukucaphula: Yintoni isifo sika-Alzheimer?Jonga kolu lwazi.Abantu bemihla ngemihla kwi-Intanethi.2023-09-20
Qaphela ukuba kukho uhlobo lweebhaktheriya ezinokungena kumqobo wegazi-ubuchopho
Kutshanje, abaphandi abavela kwi-Baylor College of Medicine e-United States bapapashe iphepha lophando elinesihloko esithi: I-Toll like receptor 4 kunye ne-CD11b echazwe kwi-microglia coordinate erasure ye-Candida albicans cerebral mycosis kwijenali yeeNgxelo zeSeli.
Sifumene ifungus ebizwa ngokuba yiCandida albicans enokungena ebuchotsheni ngegazi.Njengoko intetho edumileyo isitsho, “Ukukhaba umlenze wesiqhwala kunokubangela isifo sika-Alzheimer njengotshintsho.”Kolu phononongo, siphinde satyhila iindlela zemolekyuli apho iCandida albicans iqhekeza umqobo wegazi-ubuchopho kwaye ingene ebuchotsheni, ekhokelela kwisifo se-Alzheimer njengotshintsho.
Ingena njani iCandida albicans engqondweni?"Sifumene ukuba i-Candida albicans ivelisa i-enzyme ebizwa ngokuba yi-secreted aspartate protease (Saps), ephazamisa umqobo wegazi-ingqondo, ivumela i-fungi ukuba ingene ebuchosheni kwaye ibangele umonakalo," kusho uGqr. Ilebhu.
Candida albicans
I-Candida albicans (igama lesayensi: Candida albicans) ligwele elinokubangela usulelo olungenelelayo.Ngokuqhelekileyo kufumaneka kuluntu lwebhaktheriya kwi-digestive yabantu kunye ne-urogenital tracts.Malunga ne-40% ukuya kwi-60% yabantu abadala abasempilweni bane-Candida albicans kwiiphecana zabo zomlomo kunye nezokwetyisa.I-Candida albicans ihlala ihlala kunye nomzimba womntu, kodwa inokukhula ngexesha lokunqongophala komzimba kwaye ibangele i-candidiasis.Yeyona bhaktiriya ye-pathogenic ixhaphake kwi-Candida genus
Ngokophononongo kwiiNgxelo zeSeli, umngundo esidla ngokungawuhoyi kakhulu nawo usenokuba ngomnye wabaphembeleli besifo sika-Alzheimer.Abaphandi abavela kwi-Baylor School of Medicine kunye namaziko asebenzisanayo baye bafumanisa ngeemodeli zezilwanyana ukuba i-Candida albicans ingena njani engqondweni kunye nendlela eyenza ukuba isebenze iindlela ezimbini ezizimeleyo kwiiseli zengqondo ezikhuthaza ukucaciswa kwayo (okubalulekileyo ekuqondeni ukuphuhliswa kwesifo se-Alzheimer), kwaye zivelise. Iprotheyini ye-amyloid (A β) IiPeptides (amaqhekeza eprotheyini eyityhefu ye-amyloid protein) ithathwa njengondoqo wokukhula kwesifo i-Alzheimer's.
UGqr David Corry uthe.UDavid Corry unguSihlalo wePathology kwiFulbright Foundation kunye noprofesa wezifo, i-immunology, kunye neyeza kwiYunivesithi yaseBaylor.Ukwalilungu le-Baylor L. Duncan Comprehensive Cancer Centre.Ngo-2019, safumanisa ukuba i-Candida albicans ngokwenene yangena ebuchotsheni kwaye yavelisa utshintsho olufana kakhulu nesifo sika-Alzheimer.Ukudumba okubangelwa yiCandida albicans kaninzi kuhamba
A β Isizathu sokuveliswa kwe-amyloid efana ne-peptides kukuba i-Sap iyakwazi ukwenza i-hydrolyze i-amyloid precursor proteins (APPs).
Nangona kunjalo, ezi peptides zikwatsala ingqalelo yeeseli zomzimba zobuchopho - i-microglia, ebalulekileyo ekususweni okulandelayo kweCandida albicans yingqondo ngokwayo.Ukongeza, i-toxin yeCandidalysin eveliswe yiCandida albicans ivula i-microglia ngenye indlela.Ukuba le ndlela iphazamisekile, i-fungi kwingqondo ayikwazi ukupheliswa.
Abaphandi babonisa ukuba lo msebenzi unokuba yiphazili ebalulekileyo yokuqonda ukwenzeka kwesifo sika-Alzheimer.Uphononongo lwangaphambili lucebise ukuba iiproteases ebuchotsheni zibandakanyeka ekwahlukaneni kwe-apps kwaye zibe negalelo ku-A β Ukuqokelelwa kwento iye yabeka isiseko.Kwaye ngoku inokuqinisekiswa ukuba le protease yangaphandle evela kumngundo inokubangela imveliso ye-A β Peptide.
Abaphandi babonisa ukuba uvavanyo olongezelelweyo lwendima ye-Candida albicans kuphuhliso lwesifo se-Alzheimer luyafuneka kwixesha elizayo, elinokuthi likhokelele kwiindlela ezintsha zonyango ze-AD.
Izixhobo ezibhekiselele:
[1] Yifan Wu et al, Umrhumo onjengommkeli 4 kunye ne-CD11b echazwe kwi-microglia yokulungelelanisa ukucima i-Candida albicans cerebral mycosis, iiNgxelo zeSeli (2023) DOI: 10.1016/j.celrep.2023.113240
[2] Iimveliso zosulelo lobuchopho obusebenzayo Isifo sika-Alzheimer njengotshintsho, yithi isifundo esitsha Ifunyenwe ngo-Oktobha 17, 2023 ukusuka https://medicalxpress.com/news/2023-10-brain-fungal-infection-alzheimer-disease-like.html
Ixesha lokuposa: Dec-22-2023